Colquhoun and MacBryde met in 1933 as students at Glasgow School of Art. Their lifelong bond developed so quickly that they were awarded a joint travelling scholarship five years later. However, the outbreak of the Second World War interrupted their artistic development. MacBryde was declared medically unfit, whilst Colquhoun served under a year with the Royal Army Medical Corps before being invalided out.
In the meantime, MacBryde had achieved an entrée into London’s art world and they moved within the contemporary art collector and patron Peter Watson in the English capital in 1941. They quickly became friends with artists including Francis Bacon, John Craxton, Lucian Freud, John Minton and Keith Vaughan, as well as habitués of the pubs and clubs of Soho. Their work was shown in group, joint and solo exhibitions throughout the 1940s including at the progressive Lefevre Gallery. Paintings by Colquhoun were acquired by the Contemporary Art Society and the Council for the Encouragement of Music and the Arts (which became the Arts Council of Great Britain) in 1942.