Intended as a rival to the London-based Gentleman's Magazine, in order that "our countrymen might have the production of every month sooner, cheaper and better collected than before," in practice much of its content was reprints of articles and letters from the Gentleman's Magazine and other English periodicals. Popular through the 18th century, the monthly magazine reported on world events, contemporary politics, learned societies, new publications and introduced a register of births, marriages and deaths, a feature which other journals soon copied. Issues occasionally contained maps, plans and other illustrations.
Given Scotland's leading role in emigration to North America, the editors of the Scots Magazine inevitably took a keen interest in events in what is now Canada and the United States of America. The August 1776 issue reproduces the text of the American Declaration of Independence, and the September issue for that year included a folding map of North-East America including Philadelphia, New Jersey and New York. After the establishment of the new American republic, the editors of the magazine were generally well disposed to the country, the November 1791 issue reported that "the prosperity of this country has far overstepped the most sanguine expectations of its warmest advocates" and Alexander Hamilton "is not inferior to Pitt or Necker, either in integrity or abilities."